It was an easy way to slash GWP and avoid EPA fines. R407A has a GWP of ~2,100, which is nearly half of R404A, and it works efficiently in medium-temperature applications like milk and produce cases.

Usually, yes. Because R407A has different mass flow rates than R404A, you often need to swap the TXV power assembly or adjust the superheat significantly to prevent liquid "slugging" from damaging the compressor.

It runs much hotter than R404A. In low-temp (freezer) applications, you often need demand cooling or liquid injection to keep the compressor from overheating, especially during the peak of the U.S. summer.